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Abstract            Volume:14  Issue-9  Year-2026         Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcret@gmail.com

Tuberculous Addison’s Disease Presenting as Primary Adrenal Insufficiency: A Case Report From a Tuberculosis-Endemic Region
Subramanya Bharadwaj Mukkamala1, Akella L. N. Priyanka2 and Y. Vishnu Vardhan3*
1Consultant, Department of General medicine, LG Hospitals, Visakhapatnam, Andhra Pradesh, India
2Consultant, Department of Pathology, Unipath Speciality Laboratory, Visakhapatnam, Andhra Pradesh, India
3Professor, Department of Community Medicine, Sri Balaji Medical College Hospital & Research Institute, Tirupati, Andhra Pradesh, India
*Corresponding author
Abstract:

Primary adrenal insufficiency is a rare but life-threatening disorder, most often autoimmune in developed countries but still frequently caused by tuberculosis in endemic regions. We report a 42-year-old man with previously treated spinal tuberculosis who presented with progressive hyperpigmentation, fatigue, and recurrent presyncope. Evaluation revealed diffuse pigmentation, postural hypotension, low cortisol, markedly elevated ACTH, hyponatremia, hyperkalemia, and high plasma renin activity. CT showed bilateral adrenal enlargement with central necrosis, and biopsy confirmed caseating granulomas diagnostic of adrenal tuberculosis. The patient improved with anti-tuberculosis therapy and steroid replacement, highlighting the importance of considering adrenal tuberculosis in the differential diagnosis of Addison’s disease in tuberculosis-endemic regions.

Keywords: Addison’s disease, adrenal tuberculosis, primary adrenal insufficiency, hyperpigmentation, postural hypotension
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How to cite this article:

Subramanya Bharadwaj Mukkamala, Akella L. N. Priyanka and Vishnu Vardhan Y. 2026. Tuberculous Addison’s Disease Presenting as Primary Adrenal Insufficiency: A Case Report From a Tuberculosis-Endemic RegionInt.J.Curr.Res.Aca.Rev. 14(9): 27-31
doi: https://doi.org/10.20546/ijcrar.2026.1409.003
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.


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