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Abstract            Volume:10  Issue-8  Year-2022         Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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Phytochemical Studies and Evaluation of the Hypoglycemic Activity of the Methanolic Extract of Tetrapleura tetraptera Bark ((Schumach & Thonn.) Taub., 1891)
Yeo Sounta Oumar1, 2*, Konan N’dri Seraphin1, Mawa Traoré1, Silué Kalamourou1,
Doumbia Idrissa1,2, Djaman Allico Joseph1,3 and Coulibaly Adama1,2
1University of Man, PO Box 20 Man, Côte d'Ivoire.
2Biochemical Pharmacodynamy Laboratory, Biosciences Department, Felix Houphouet-Boigny University, PO Box 582, Abidjan 22, Côte d'Ivoire
3Biochemical Laboratory of Pasteur Institute of Côte d'Ivoire, PO Box 490, Abidjan 01, Côte d'Ivoire
*Corresponding author
Abstract:

The aim of this study was to estimate the possible hypoglycemic effect of the methanolic extract of Tetrapleura tetraptera bark in rats made diabetic by streptozotocin. Initially, our study focused on a triphytochemistry of our extract. It showed that the methanolic bark extract is richer in polyphenols, flavonoids, quinones, saponosides, stereol-polyterpens, gall tannins and catechic tannins but poor in alkaloids and anthocyanins. We found that the methanolic extract of the bark has a dose-dependent hypoglycemic activity. First, experimental diabetes was induced in male Wistar rats by intraperitoneal injection of STZ (50mg/kg). Treatment with a methanolic extract of the plant was given orally at daily doses of 250, 500, 750 mg/kg/pc for 14 days. The results obtained, clearly show that streptozotocin induces in animals, a diabetes characterized by hyperglycemia. However, the oral administration of doses of methanolic bark extract for 14 days caused a clear decrease in serum glucose concentration.

Keywords: Phytochmical studies, Activité Hypoglycémiante,Tetrapleura tetraptera bark.
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How to cite this article:

Yeo Sounta Oumar, Konan N’dri Seraphin, Mawa Traoré, Silué Kalamourou, Doumbia Idrissa, Djaman Allico Joseph and Coulibaly Adama. 2022. Phytochemical Studies and Evaluation of the Hypoglycemic Activity of the Methanolic Extract of Tetrapleura tetraptera Bark ((Schumach & Thonn.) Taub., 1891).Int.J.Curr.Res.Aca.Rev. 10(8): 1-12
doi: https://doi.org/10.20546/ijcrar.2022.1008.001
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.


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