Abstract            Volume:4  Issue-4  Year-2016         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

Bisphenol-A (BPA) is a high molecular polymer organic compound widely used all over the world. The purpose of this study was to investigate the hematological, biochemical and histological alterations in pregnant rats induced by BPA which is an estrogenic environmental contaminant.  Pregnant rats were administrated orally BPA (50 mg/kg/day.b.wt and 500mg/kg/day.b.wt). After 9 consecutive days of exposure, blood, sera and tissues were collected for hematological, biochemical and histopathological examination. Lymphocytes were separated from the spleen for rosset formation test. BPA- treated rats showed a significant reduction in red cell count, hemoglobin concentration and packed cell volume. The serum activity of alkaline phosphatase, low-density lipoprotein levels showed increased in BPA-treated groups concomitant with reduction in glucose levels. Leucogram, E-rosettes forming count and high-density lipoprotein values did not show significant differences but alter albumin & globulin levels. Histopathological alterations were detected in liver and spleen of BPA-treated rats. From the present study it could be concluded that exposure to BPA is accompanied with anemia, liver and spleen injuries in pregnant rats.

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