Abstract            Volume:9  Issue-11  Year-2021         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

Bacterial diseases are an oversized burden of morbidity and mortality globally. The emergence of antimicrobial resistance may be a major public unhealthiness worldwide, particularly in low-and middle-income countries. Therefore, screening of energetic antimicrobial drugs from herbal sources is important. Thus, this study was aimed to evaluate the antibacterial activity of medicinal plant: Stephania abyssinica is employed in Ethiopian traditional medicine for the treatment of stomachache, headache and ant -microbial. Dried leaves of the plant were extracted using maceration technique. The powder was soaked in methanol 1:10 solute-solvent ratio then, placed on a shaker for 72 hours. The filtered extracts were concentrated during a rotary evaporator and lyophilizer for alcoholic and aqueous extracts respectively. Antibacterial activity test was conducted against selected human pathogenic bacterial species (standard strains) using the agar-well diffusion. Furthermore, the extracted phytochemical content was identified and safety of the plant was tested on Swiss albino mice. Phenol, Flavonoids, terpenoids, alkaloids, steroids, saponins, tannins, steroidal glycosides and glycosides were detected in plants extract. Plants leave extracts were not toxic up to 2000mg/kg on the test mice.

Download this article as