Abstract            Volume:9  Issue-9  Year-2021         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

Scientific reports suggest that Xylocarpus moluccensis has numerous important biological activities, including antioxidant, anti-inflammatory, anti-microbial, anti-cancer, anti-diarrheal, insecticidal, antifeedent, neuropharmacological (e.g., CNS depressant), anti-atherosclerotic, and lipid-lowering activity. Anxiety disorders are common and disabling psychiatric conditions that are often associated with depressive symptoms. The aim of the present study was to investigate the anxiolytic-like effects of the methanolic bark extract of X. moluccensis (MEXM) in different behavioral paradigms in Swiss albino mice. For this, adult mice of either sex were treated with MEXM (250 and 500 mg/kg, p.o.) and/or diazepam (2 mg/kg, i.p.), and subjected to a number of behavioral studies. In the open-field test, the number of square field cross, grooming, and rearing, was counted, while in the light/dark and swing tests, the time spent in the dark portion and the number of swings were calculated, respectively. Findings from this investigation revealed the presence of flavonoids, phenols, saponins, terpenes (including triterpenes), and gums in MEXM. In addition, MEXM caused a significant (p < 0.05) anxiolytic-like effect in experimental animals, where it dose-dependently increased the total time in the center and decreased the number of rearing and grooming’s responses in the open field test. The MEXM also increased the dark residence time and decreased the number of swings in a dose-dependent manner. A dose of 500 mg/kg of MEXM caused the highest calming effect was when combined with the diazepam group. Taken together, these results extend our understanding of the effects of X. moluccensis on the central nervous system and suggest that this plant may be useful for the management of neurological diseases and disorders, especially anxiety.

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