Abstract            Volume:6  Issue-8  Year-2018         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

Over past few decades, the problems posed by multi-drug resistant microbes have reached an alarming level in many countries around the world. The use of most antimicrobial agents is limited not only by rapidly developing drug resistance but also by the unsatisfactory treatment of microbial infections. In pursuit of this goal, our research efforts are focused on the development of novel structural moieties with diverse activities. Literature survey revealed that various heterocyclic members such as pyrazole, imidazole, triazole, thiadiazole, thiazole are predominantly imperative antibacterial and antifungal agents including azoles derivatives like tazobactam, cefatrizine, rufinamide, fluconazole, itraconazole, voriconazole, posaconazole and ketoconazole. 1,2,4 triazole derivatives is five membered heterocyclic ring among various heterocycles that have received most attention during last two decades as potential antimicrobial, antifungal, analgesic, anticonvulsant, diuretic, antimalarial. Synthesis of benzothiazole derivatives have long been focused for interest of research in the field of medicine, especially 2-substituted benzothiazole derivatives with fluoride functional group as substituent. After extensive literature survey it was observed that not enough efforts are made to combine these two moieties as a single molecule to identify the new Candidate that may be value in designing new, potent, selective and less toxic drug. Quinoline derivatives have also demonstrated a variety of biological properties that includes antimalarial, antibacterial, anti-inflammatory, anti-tubercular etc. The biconjugation aimed as ligation of two or more compounds to form new complex with combined properties of their individual components.

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