Host  modulatory  therapy  is  a  treatment  concept  that aims  to  reduce  tissue  destruction  and  stabilize  or  even  regenerate  the  periodontium  by  modifying or down regulating destructive aspects of host response and up regulating protective or regenerative responses by means of pharmacological agents. NSAIDS are effective  in  treating  periodontal  diseases  in  adjunct  to  the  nonsurgical  and  surgical  periodontal  therapy. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level. The majority of periodontal breakdown is caused by host destructive enzymes like matrix metalloproteinases (MMPs) and inflammatory mediators (prostaglandins, interleukins) that occur as a part of inflammatory response. This review will highlight the role of NSAIDS as host modulating agent." /> NSAIDS as Host Modulating Agent- A Review

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Abstract            Volume:5  Issue-5  Year-2017         Original Research Articles


Online ISSN : 2347 - 3215
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NSAIDS as Host Modulating Agent- A Review
Savitha Palanisamy1* and Jaiganesh Ramamurthy2
1Undergraduate student, Department of Periodontics, Saveetha University, Chennai, India
2Reader Department of Periodontics, Saveetha University, Chennai, India
*Corresponding author
Abstract:

Host  modulatory  therapy  is  a  treatment  concept  that aims  to  reduce  tissue  destruction  and  stabilize  or  even  regenerate  the  periodontium  by  modifying or down regulating destructive aspects of host response and up regulating protective or regenerative responses by means of pharmacological agents. NSAIDS are effective  in  treating  periodontal  diseases  in  adjunct  to  the  nonsurgical  and  surgical  periodontal  therapy. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level. The majority of periodontal breakdown is caused by host destructive enzymes like matrix metalloproteinases (MMPs) and inflammatory mediators (prostaglandins, interleukins) that occur as a part of inflammatory response. This review will highlight the role of NSAIDS as host modulating agent.

Keywords: Host modulation, NSAIDS, Periodontal disease, non surgical and surgical periodontal therapy
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How to cite this article:

Savitha Palanisamy and Jaiganesh Ramamurthy. 2017. NSAIDS as Host Modulating Agent-A Review.Int.J.Curr.Res.Aca.Rev. 5(5): 97-100
doi: https://doi.org/10.20546/ijcrar.2017.505.013
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.


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