Abstract Volume:5 Issue-5 Year-2017 Original Research Articles
NSAIDS as Host Modulating Agent- A Review
1Undergraduate student, Department of Periodontics, Saveetha University, Chennai, India
2Reader Department of Periodontics, Saveetha University, Chennai, India
Host modulatory therapy is a treatment concept that aims to reduce tissue destruction and stabilize or even regenerate the periodontium by modifying or down regulating destructive aspects of host response and up regulating protective or regenerative responses by means of pharmacological agents. NSAIDS are effective in treating periodontal diseases in adjunct to the nonsurgical and surgical periodontal therapy. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level. The majority of periodontal breakdown is caused by host destructive enzymes like matrix metalloproteinases (MMPs) and inflammatory mediators (prostaglandins, interleukins) that occur as a part of inflammatory response. This review will highlight the role of NSAIDS as host modulating agent.
Keywords: Host modulation, NSAIDS, Periodontal disease, non surgical and surgical periodontal therapy
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