IJCRAR is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCRAR Articles.

INDEXED IN INDEX COPERNICUS - ICI Journals Master List 2016 - IJCRAR--ICV 2016: 81.15 For more details click here

Abstract            Volume:5  Issue-4  Year-2017         Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcret@gmail.com

Effect of Miltefosine on Growth and Metabolism of Leishmania donovani and Leishmania tropica Promastigotes
Husain F. Hassan* and Marowa E. Abdulla
Department of Biology, College of Science, University of Kirkuk, Iraq
*Corresponding author
Abstract:

Miltefosine was found to be potent inhibitor of Leishmania donovani and Leishmania tropica promastigotes growth in vitro. Miltefosine was found to be equally effective against both parasites with ED50> 0.0001 mg/ml. The results demonstrated that the effect of miltefosine may be attributed to the inhibition of the enzyme diethylacetonephosphate acetyltransferase, that lead to the damaging membrane phospholipid biosynthesis, thus causing cellular death. The results suggest that miltefosine might be a promising potential as antileishmanial drug.

Keywords: Leishmania, Promastigotes, Metabolism, Miltefosine.
Download this article as Download

How to cite this article:

Husain F. Hassan and Marowa E. Abdulla. 2017. Effect of miltefosine on growth and metabolism of Leishmania donovani and Leishmania tropica promastigotes.Int.J.Curr.Res.Aca.Rev. 5(4): 95-101
doi: https://doi.org/10.20546/ijcrar.2017.504.014
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.


Quick Navigation


Quick Navigation