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Abstract                 Volume:5  Issue-4  Year-2017          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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In vitro Anticancer Activity of Marine Fungus Penicillium cyaneum
A. Xavier Fernandes1*, S. Mohamed Salique1 and K. Umamagheswari2
1Department of Botany, Jamal Mohamed College (Aut.), Trichy - 620 020, Tamil Nadu, India
2Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli, 627 012, India
*Corresponding author
Abstract:

Cancer is one of the most life-threatening diseases worldwide. Over the last few years, several metabolites produced by marine fungi have displayed potent anticancer effects. In the present study the anticancer activity of marine fungus Penicillium cyaneum against HepG 2 cells (human liver carcinoma cells) was assessed by in vitro cytotoxicity assay. The results revealed that P. cyaneum ethyl acetate extract showed potent cytotoxic effects in HepG 2 cells, with cell viability (29.5%) observed at 1000µg/mL. The IC50 of ethyl acetate extract of P. cyaneum was 242.24 μg/mL.

Keywords: Cancer, marine fungus, HepG 2, cytotoxicity.
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How to cite this article:

Xavier Fernandes, A., S. Mohamed Salique and Umamagheswari, K. 2017. In Vitro Anticancer Activity of Marine Fungus Penicillium cyaneumInt.J.Curr.Res.Aca.Rev. 5(4): 76-81
doi: https://doi.org/10.20546/ijcrar.2017.504.011