Abstract            Volume:4  Issue-2  Year-2016         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

Cytarabine (Ara-C) is a chemotherapeutic agent predominately used for the treatment of acute myeloid leukemia and lymphoblastic leukemia. In this work, a new method of synthesis seven Ara-C Schiff base derivatives and study their effect on inhibiting the growth on certain pathogenic bacteria were described. Almost all analysed compounds inhibit the health of the studied bacteria significantly. Synthesised compounds were subjected to a stability study in phosphate buffer (0.2 M, pH 7.4) and in KCl/HCl buffer (0.2 M, pH 1.2) at different time intervals (0 – 240 min) incubated at 37°C. This revealed that all synthesised compounds are significantly stable and have longer t _1/2 in comparison with Ara-C. In vitro cytotoxicity results showed that the new prodrug had a much less toxicity and may be considered for further biological screening and application trial.

Download this article as