Abstract            Volume:13  Issue-7  Year-2025         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

The pharmaceutical industry operates under stringent regulatory requirements to maintain sterile environments and safeguard product quality. Microbial contamination in controlled areas poses significant risks to both patient safety and manufacturing outcomes. Among the strategies adopted, fogging and mopping are widely implemented disinfection techniques for reducing microbial load across surfaces and enclosed spaces. This article provides a structured review of the calculation methods required to determine the appropriate quantity of disinfectant solution for fogging and mopping applications in pharmaceutical facilities.For fogging, calculations are based on room volume, application rate, and fogger flow rate, enabling precise estimation of disinfectant quantity and fogging duration. The study illustrates these steps through practical examples, emphasizing the role of ULV foggers in producing fine aerosols (3–15 ?m) to ensure efficient coverage of inaccessible surfaces. For mopping, the article outlines a methodology derived from field practices, including surface area estimation for floors, walls, and ceilings, to guide accurate disinfectant usage. The findings highlight that accurate volume-based calculations are critical for optimizing disinfectant efficiency, minimizing wastage, and ensuring compliance with Good Manufacturing Practices (GMP). Ultimately, fogging should complement, not replace, routine cleaning and disinfection, serving as a supplementary safeguard for contamination control in pharmaceutical manufacturing environments.

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