Abstract            Volume:13  Issue-5  Year-2025         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

The convergence of green nanotechnology and traditional medicine offers new therapeutic strategies for metabolic disorders such as type 2 diabetes mellitus (T2DM). This study investigates the antidiabetic potential of calcium nanoparticles (CaNPs) synthesized using a green method with Momordica cymbalaria, an Ayurvedic plant renowned for its hypoglycemic properties. Nanoparticles were synthesized from both root and seed extracts and characterized via UV–Vis spectrophotometry. A Drosophila melanogaster high-sugar diet model was employed to simulate diabetic phenotypes. Diabetic flies exhibited impaired locomotor function and metabolic imbalance, which were significantly reversed upon treatment with CaNPs, particularly from root-derived formulations. Enzymatic assays demonstrated potent inhibition of α-amylase and α-glucosidase (non-competitive and mixed-type, respectively). CaNPs also showed high DPPH radical scavenging activity and restored catalase and glutathione peroxidase levels. Nitric oxide and glucose concentrations were markedly reduced, with glucose levels dropping from ~196.1 to ~16.2 mg/dL. These results highlight the therapeutic potential of plant-based CaNPs and validate Drosophila as a preclinical screening model for Ayurvedic nanomedicine.

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