Abstract            Volume:12  Issue-3  Year-2024         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

Introduction: Herbs have been a source of medicinal compounds for centuries. Herbal therapy has been reported to treat fertility problems, liver disease, central nervous system disorders, digestive and metabolic disorders. Researchers are currently focusing on the medicinal properties of potentially bioactive plant products with excellent therapeutic properties. Mimosa pudica is a creeping annual or perennial herb. The aim of this study is to determine the effects of Mimosa pudica in sulphanamide-induced male infertility in wistar rats. Methods: Forty-two wistar rats were used for the study and distributed into seven different groups with different pattern of treatments: Group 1: Rats taking water only (negative control). Group 2: Rat and Sulphonamides (positive control). Group 3: sulphanamide (3000mg) and silymarin (210mg). Group 4: Sulphanamide (3000mg) and aqueous extract of Mimosa pudica (100mg). Group 5: sulphanamide (3000mg) and aqueous extract of Mimosa pudica (200mg). Group 6: sulphanamide (3000mg) and aqueous extract of Mimosa pudica (300mg). Group 7:100mg/kg of the aqueous extract of Mimosa pudica. Result: Rats that were induced with sulphoanamide & Silymarin and sulphoanamide & Plant (300mg) has the highest mean level of testosterone (20.0±1.4) compared to other groups while rats that were induced with sulphoanamides only has the lowest mean level of testosterone (3.7±1.6) compared to other groups (p<0.001). Rats that were induced with sulphoanamides only has the highest mean level of Prolactin (25.0±2.4) compared to other groups while those that were in the control group has the lowest mean level of Prolactin (7.8±2.6) compared to other groups (p<0.001). Rats that were induced with plant extract (100mg) only has the lowest mean±SD of LH (6.7±0.5) compared to other groups, those in the control groups, rats induced with sulphoanamides & plant extract (200mg), and sulphoanamides & plant extract (300mg) has the same mean level of LH (6.0±0.7), while the rats induced with only sulphoanamides the lowest mean level of LH (3.8±1.2) compared to other groups (p<0.001). Also, rats induced with sulphoanamides & plant extract (300mg) has the highest mean level of FSH (12.2±1.2) compared to other groups, rats induced with sulphoanamide & silymarin and those induced with sulphoanamides & plant extract (100mg) has the same mean level of FSH (11.0±0.9), while the rats induced with only sulphoanamides the lowest mean level of FSH (0.9±0.1) compared to other groups (p<0.001).

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